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the modified soluble hyaluronidase is formulated for systemic adminsitration in a sufficient amount to maintain at least or about 3 LVmL in the plasma, generally 3 LVmL- 12 LVmL or more, for example, from about or at a level of 4 LVmL, 5 LVmL, 6 LVmL, 7 LVmL, 8 LVmL, 9 U/mL, 10 U/mL, 11 U/mL, 12 U/mL, 13 U/mL, 14 U/mL, 15 U/mL, 16 U/mL, 17 U/mL, 18 U/mL, 19 U/mL, 20 U/mL, 25 U/mL, 30 U/mL, 35 U/mL, 40 U/mL, 45 U/mL, 50 U/mL or more